Young adults Neurology

Presentation

cognitive

ischemic

small vessels

medium vessels

large vessels

Hematologic

embolic

cardiac

EKG

r

arrythmia: intermittent Afib. Flutter.

2Decho, TTE

r

Cardiomyopathy, Congenital, Endocarditisbubble studies for the shunts.

Pregnancy related

r

Fat, amniotic or air emboliccoagulopathy w/o in pregnancy  is invalidCT contrast is contradicted.

movement ds

dopa responsive

Huntington

Wilson

Acanthocytosis

imaging

CTA/MRA

Moyamaoya

vasculitidis

r

MRA of the abdomen for r/o systemic vasculitis

Dissection

MRV

r

non vascular distribution ischemia +/- bleeding.hypercoagulablity w/p.

MRI

white matter lesions

MS

CADASIL

r

CADASIL: WM lesion are lacunes that can mimic MS on MRI; lesions affects tips of anterior temporals symmetrically. characteristiclly h/o maigraine like headache and h/o early family CVA.the characteristic lacunes are sub cortical which differentiate it from the deep lacunes from HTN.presentations: migraine, early CVA; early dementia of fronto- temporal type.etiology: NOTCH3 gene on chromosme 19dx: genetic, less effectively is skin biopsy.tx: Acetazolamide for the headacheretinal-vasculopathy with cerebral leukodystrophyis asimilar diseasel to CADASIL were the retina is affedted as well but the genetic test is neg.

Neuro raheumatolgic

late onset metabolics

r

Alexander, Adrenoleuko dystrophy

PRES

r

Hypertension encephalopathy (esp renal realted)PreclampsiaDrugs related (cyclosporine)

CT

calcification

Labs:

hematologic

r

CBC, Blood smear, Hg electrophyresis

Coagulation

r

CBC, TTP, INR, haptoglubin, FDP, LDH, Coomb;s testprot C, S; factor 5, antirhombophylin, anti phospholipid

Microangiopathic

r

sx: TTP, DIC

thrombophilia

r

Prot C, S deficiency

Minerals

ceruplasmin, copper

r

for Wilson, Mencke's.

Vitamins

r

B12, Folic, Thiamin, Ein babies with sz: vit 6

Endocrine

r

Thyroid panel, PTH, Cortisone

Inflammatory

r

ESR, CRP, SPEP, UPEP, ANA, RF, anti DNAs,

Auto Antibodies

Neuropathies

r

Anti Mag, Anti QM1, Anrti QD a/b;

CSF

r

Routine: prot, gluc, cells, lactate, c/sIgG index, IgG synthesis, oligoclonal, MBP, prot 14-3-3;VDRL, PCR (HSV1-2, HZV, Entero, TB), cryptococcus, measles.CSF IgG needs serum IgG and Albumin.

Muscle

r

CK, lactate, Pytophate

Drugs & Toxic

r

cocaine, Heroinheavy metals, CO (carboxy Hg)

Metabolic

r

AA, urine organic acids, Lysosomes,

Electrophysiology

EEG

SZ

non convulsive status

r

Absence/CPT status.

encephalopahy

r

SSPE, CJD

EMG

NCS

Myopathy

VER

r

the p100 wave delay helpful for quantify the response to tx and progress.For non cooperatives and children: the falsh light is the only possible and it's only positive or neg.