Module 2 Mind Map

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Spring 2016 Final Concept Map - Public

von Pamela Harvey

Pharmacodynamics

von Juan Longoria

Improved Patient care

von Bronagh Bolger

Introductory biology is the study of biomolecules and cellular components that work together to enable the translation of proteins that are the building blocks of living organisms. Through the idea of central dogma and regulation processes that make sure every step of a process is done correctly so that mutation cannot occur, living organisms can produce and live a healthier life.

von DJ Zayas

Pharmacodynamics - Drug Theory

Population effect > Dose Response

I mentioned in a previous slide that drug responses are not all or nothing, they are graded, however desired pharmacological outcomes very often are indeed all or nothing. Either there is pain or no pain, either the patient is awake or asleep and whilst drugs can dose dependently cause graded levels of pain or consciousness you are only clinically interested in the maximal effect. When administering a general anesthetic for example, all you are interested in is whether the patient is conscious or unconscious. Where an effect is all or nothing for practical purposes, an individual dose response analysis may not be appropriate but a population response is of clinical value.

Affinity, Efficacy, Potency

Affinity: Affinity is how avidly a drug binds its receptor or how the chemical forces that cause a substance to bind its receptor.

Potency

Efficacy

Receptor occupancy vs tissue effect

As we discussed in the previous slide, receptor occupancy may or may not relate to tissue response. Even if it does directly correlate, the dose administered may not be remotely similar to the actual amount of drug that reaches the target site. So without therapeutic blood monitoring, clinically all we know much of the time is the dose administered and the response achieved. This can be plotted of course and whilst the curve may bear similarity to the receptor occupancy curve, the ED50, the dosage required to achieve 50% tissue response will often be orders of magnitude different from the dosage required to achieve 50% receptor occupancy. Notably however the shape of the curve is similar, and a log scale is also used again because the effects tend to occur within a narrow concentration range.

Laws of Mass Transfer

Eq. 3: Hill Langmuir equation. Percentage occupation of receptors by a drug is, logically equal to the number of drug bound receptors divided by the total number of receptors

Eq. 2: the ratio of occupied receptors to unbound receptor and drug equals the ratio of dissociation and association rate constants, which in turn are equivalent to the dissociation constant

Eq. 1: the rate of the reaction is proportional to the product of the concentration of reactants