Omeprazole

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Pharmacokinetics (cont.)

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Proton Pump Inhibitor (PPI) OMEPRAZOLE Used to decrease gastric acid production

Pharmacotherapeutics

Ulcers associated with H. pylori

GERD

Heartburn

Pharmacokinetics

Best absorped in the smal intestine

Metabolized through P-450 system

Half life = < 2 hrs

High first pass effect

Highly protein bound

Food effects the absorption rate, but does not effect the extent of absorption

Pharmacodynamics

Increases gastric pH

Inhibits both basal and stimulated acid secretion irrespective of the stimulus

Inhibits the final phase of gastric acid production through supression of the parietal H +, K + ATPase system

Selectively and irreversibly inhibits the proton pump

Core Patient Variable

Asians have a longer duration of action

Pregnancy

Note the pt.'s age: - Efficacy and safety in children not established - Elderly must be screened for bone density

Nursing Management

Screen for pregnancy

Teach pt. to not chew or crush pills

Screen for sensitivity to Omeprazole

Instruct patient to take dose prior to eating

Contraindications

Pregnancy category C

Hypersensitivity to the drug's components

Breastfeeding

Major Adverse Effects

Increased risk for C. diff infection

Dizziness

Nausea

Osteoporosis

Headache