Gout

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90% of cases of gout are caused by inefficient renal excretion of urate vs. overproduction

*Gout Risk Factors: -Male Gender -Age -Obesity -Ethnicity (Pacific Islanders) -Polymorphisms (Genetics) -Kidney Disease

urate Crystal Formation

Elevated Uric Acid Levels

Uric Acid

Xanthine

Hypoxanthine

Endogenous Purines Synthesis

Tissue Nucleic Acids

Dietary Purines

Gout

Acute Gout

steroids

Colchicine

NSAIDs

Chronic Gout

Allopurinol

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