Gout

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90% of cases of gout are caused by inefficient renal excretion of urate vs. overproduction

*Gout Risk Factors: -Male Gender -Age -Obesity -Ethnicity (Pacific Islanders) -Polymorphisms (Genetics) -Kidney Disease

urate Crystal Formation

Elevated Uric Acid Levels

Uric Acid

Xanthine

Hypoxanthine

Endogenous Purines Synthesis

Tissue Nucleic Acids

Dietary Purines

Gout

Acute Gout

steroids

Colchicine

NSAIDs

Chronic Gout

Allopurinol

Probenecid

Febuxostat

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