Organigram

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650 2) Target Heart Rate - with validation

luonut Gary Sibbitts

THE CIRCULATORY SYSTEM

luonut Henry Hubbell

Dogs - endotherm in hot conditions

luonut Anastasiya Dyadchenko

Heart

luonut JD - 10WI 758754 Jean Augustine SS

Heart failure with reduced ejection fraction

Renin angiotensin aldosterone system

angiotensin ll

Valsartan( inhibit angiotensin ll)

AT2 receptor

increase vasoconstriction

increase heart hypertrophy

increase aldosterone

increase blood pressure

Natriuretic peptide system

natriuretic peptides

Sacubitril( inhibit enzyme neprilysin) produce inactive fragment

increase bradykinin and angiotensin ll

increase vasodilation

decrease heart hypertrophy

decrease aldosterone

decrease blood pressure