Organigram

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circulatory system

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Heart failure with reduced ejection fraction

Renin angiotensin aldosterone system

angiotensin ll

Valsartan( inhibit angiotensin ll)

AT2 receptor

increase vasoconstriction

increase heart hypertrophy

increase aldosterone

increase blood pressure

Natriuretic peptide system

natriuretic peptides

Sacubitril( inhibit enzyme neprilysin) produce inactive fragment

increase bradykinin and angiotensin ll

increase vasodilation

decrease heart hypertrophy

decrease aldosterone

decrease blood pressure