によって Jenny Doriot 17年前.
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Prions
Prions
caused by conversion of glycoprotein PrPc into an infectious form PrpSc
recent evidence suggests PrPc is involved in regulating cell death
Prpc located on chromosome 20 in humans
1982 Prusiner--Scrapie in sheep caused by prions
spongiform encephalopathies because large vacoules formed in brain\\
Human disease
can be hereditary but not necessarily all the time
fatal familial insomnia
Gerstmann-Straussler-Scheinker syndrome
Creutzfeldt-Jakob disease
kuru
Scrapie was reduced with proteases but not radiation which meant that the infection was a protein
