PET Radiopharmaceuticals

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The Mind Project

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Drugs Concept Map

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Factors that Influence Human Development

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PET Radiopharmaceuticals

Ga-68 Dotatate

Localization of somatostatinreceptor positive neuroendocrine tumors (NeTs)

Somatostatin receptor.

68 Min.

N-13 Ammonia

Myocardium rest and stress imaging and evaluate for CAD.

Analog of ammonia. Distributed to all organs. Diffusion across capillary membrane, then metabolic conversion.

9.96 Min.

Rb-82 Chloride

Myocardium rest and stress imaging and to evaluate for CAD.

Analogous to Potassium (K+). Ion exchange.

Half-Life:

76 Sec.

F-18 Fluciclovine(Axumin)

Imaging in men for prostate cancer (based on PSA levels).

Amino acid transport across mammalian cell membranes.Taken up by prostate cancer cells.Active transport.

F-18 Sodium Fluoride

Skeletal imaging- Define areas of altered osteogenic activity.

Accumulates in skeleton in an even fashion. Ion exchange.

Half Life:

F-18 Florbetapir(Amyvid)

Alzheimer’s & cognitive decline disorders. Estimate B-amyloid neurotic plaque.

Binds to B-amyloid plaques in the brain. Passive diffusion.

F-18 Florbetaben(Neuraceq)

Estimating B-amyloid plaque density in patients with cognitive decline. (Alzheimer’s).

Binds to B-amyloid plaques in the brain. Crosses the BBB. Passive diffusion.

F-18 FDG

Uses:

Abnormal glucose metabolism

Cardiac viability- CAD and L. ventricular dysfucntion.

Brain imaging- associated with foci of epileptic seizures.

Oncology- Assessment of with suspected cancer.

MOL:

Glucose analog. Metabolism. Passive diffusion

Half life:

110 Min.