Receptor Theory

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Chapter_5__Names_Bindings_and_Scopes

af Levi George

Module 2 Mind Map

af Jared Hall

gym

af Jonathan Kong - T L Kennedy SS (2352)

Module 2 Mind Map

af Jared Hall

Receptor Theory

Safety

Certain safety factor

Therapeutic Index

Desensitization

physiological adaptation

altered drug metabolism

exhaustion of mediators

translocation of receptors

altered conformation of receptors

tolerance

Combinations

synergistic/potentiating

additive

Antagonism

chemical

physiological

signaling blockade

pharmacokinetic

allosteric

Potency

effective concentration

effective dose

Quantitative aspects

Drug Receptor interaction

equilibrium dissociation constant

logarithmic

linear

Drug-receptor binding

Activation

governed by efficacy

Occupation

governed by affinity

Drug targets

enzymes

carriers/transport molecules

Ion channels

Membrane receptors

Specificity defined by:

site specificity

ligand specificity

High structural conservation

Paul Ehrlich proposed:

Drugs don’t have any supernatural properties by which their mere presence causes an effect

A drug will not work unless it is bound

Drugs require direct interaction with tissue