ANEMIA of CHRONIC INFLAMMATION

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cell injury

luonut Lily Ammon

Organophosphate Poisoning

luonut Brian Rystad

Paralysis

luonut Harkamal Sandhu - Lougheed MS (1486)

Concussion

luonut wyatt schuster

Treatments

Erythropoisis stimulating agents

Treat inflammation

Treat underlying cause of inflammation

Blood transfusions

DIAGNOSTIC LABS

Increased Ferritin levels

Low serum iron

Decreased Transferrin saturation

CBC - low RBCs

Brenda Mitchell

Liver

Bone Marrow

Pluripoint stem cells

Proerythroblasts

Multiple divisions

accumulates Hemoglobin

Nucleus lost

Loses mitochondria and ribosomes

Reticulocytes released into circulatory system

Mature Red Blood Cells

Spleen

Iron stored as Ferritin

ANEMIA of CHRONIC INFLAMMATION

Systemic Inflammation

Auto Immune diseases, Infections, Malignancies, Burns, Trauma

Increased Cytokine production

Decrease Iron availability

Increased RBC Destrucion

Decrease RBC productio