ANEMIA of CHRONIC INFLAMMATION

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Wound Healing

door Dave Brown

Hypersensitivity reaction

door Mashaal M Alghamdi

Anemia

door Ahmed Abo kamel

Paralysis

door Harkamal Sandhu - Lougheed MS (1486)

Treatments

Erythropoisis stimulating agents

Treat inflammation

Treat underlying cause of inflammation

Blood transfusions

DIAGNOSTIC LABS

Increased Ferritin levels

Low serum iron

Decreased Transferrin saturation

CBC - low RBCs

Brenda Mitchell

Liver

Bone Marrow

Pluripoint stem cells

Proerythroblasts

Multiple divisions

accumulates Hemoglobin

Nucleus lost

Loses mitochondria and ribosomes

Reticulocytes released into circulatory system

Mature Red Blood Cells

Spleen

Iron stored as Ferritin

ANEMIA of CHRONIC INFLAMMATION

Systemic Inflammation

Auto Immune diseases, Infections, Malignancies, Burns, Trauma

Increased Cytokine production

Decrease Iron availability

Increased RBC Destrucion

Decrease RBC productio