Schizophrenia and Cannabis

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Schizophrenia and Cannabis

Complications

Schizophrenia

Susceptible

Inc. Cannabinoid R

Inc. Endogenous cannabinoids

Genetics

Inc. Cannabinoid R.

Early use

4x

Onset Schizophrenia

Neural pruning

Drug induced psychosis

75% Psychiatric illness 12/12

50% in 3y

Short lived

Epidemiology

4% WW

Increasing

What

Problematic

Mental

Withdrawal

Anxiety, Insomnia

Unpredictable Psychosis

1 in 10

Social

Sativ and indica

Cannabinoid

Effects

Euphoria

Reduced anxiety

THC - Psychotropic effects

CBD and CBN - Sedative

Summary of Relationship

Cannabinoid System

Common brain pathology

2x

Premorbid behaviour