Hyperlipidemia

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PREGNANCY

by Cyril Chandran A/L Chandrasegaran Cyril Chandran A/L Chandrasegaran

1 month questions

by Christel Johansson

ABORTION

by Carolina Ramos

by Tanner Beckerleg

Hyperlipidemia

↓intracell cholesterol = ↑LDL receptor = ↓plasma [LDL]

Both

Niacin

Do you have a PhD in Caregiving?

Cardiac arrhythmias

Gout

Diabetes

Hepatic Disease

Peptic ulcer

Cutaneous flush, pruritis

Aspirin 30 min. prior

↓VLDL, LDL

↓TGs

Triglycerides

N3FAs

Marine Oils

Gemfibrozil

↑LDL receptors on membrane

Rash

Fibrates

Interactions

Inhibits platelet aggregation

Displaces warfarin

Arrhythmia in CAD

Flu-like syndrome

Clofibrate

Fenofibrate

NOT available in the U.S. but sold in Canada

↑HDL

PPAR-alpha

↑LPL expression

Cholesterol

Ezetimibe

Blocks cholesterol absorption @ enterocyte

Niemann-Pick C1-like protein

Bile-acid exchanger

Acidic Drugs

Thyroxine

Thiazides

Tetracycline

Iron

Hydrocortisone

Vit. A,D,E,K

Phenobarbital

Warfarin

Digoxin

Side Fx

↑VLDL

GI

Tastes like sand

Pruritis a/w biliary obstruction

Drugs

Colesevelam

Colestipol

Cholestyramine

Statin

Those with CVD should be on a statin.

Pregnancy

Myopathy

Rhabdomyolysis: 10x elevated CK, urine Mb and brown

Myositis: Pain + CK

Myalgia: Pain - CK

Myopathy: Muscle dz

Combos w/ these drugs increase risks:

Niacin (2%)

Gemfibrozil (5%)

Hepatotoxicity

↑Bone formation (women)

Anti-inflammatory

↓Smooth muscle proliferation

↓TGs

↓Thickening of vessels

↓Clotting

↓Inflammation

↓Blood pressure

↓LDL

Others

Inhibits VLDL synth.

Prava

Single day dosing

Atorva

Simva

Super-

Pitava

Rosuva

Lovastatin