Immunology

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Aff Mat

After a B cell with antigen is initially activated by at Th cell

Affinity Maturation happens in germinal center - B cell is activated by Th2, starts rapidly reproducing and mutating (regulated by Th2). The one with the highest affinity reproduces - some become plasma.

1) IgM released by B cells to make immune complexes

2) Dentric cells pick up complexes and bring to follicle to allow affinity maturation of B cells

3) If B cell has high affinity to an antigen and gets costimulation by Th2 then it starts to proliferate

HUMORAL

Parasite

Allergy

RhIgG = Hemolytic Anemia

AB

CELLULAR IMMUNITY

Integrin

ICAM/VCAM (endothelium)

Allergy (type 4 DTH)

Poison Ivy

Immune Cells

Main topic

=

Macrophages

IL-4 (humoral)

IL-12 (cellular)

Leukocytes

LYMPHOCYTES (adaptive immunity)

NK Cells

T Cell (AIRE)

CD4+ (Th0) APC: CD4/CD3 binding

no CD28 ANERGY

Parasite/Allergen IL-4 / STAT6

Th2

Unknown mechanism -

IL-4 is released in response to parasite that stimulates

IL-13

TGFB

IL-4

IL-5

IL-10

Bact/Virus phag by proAPC, which makes IFNg and IL12, which binds to STAT4 on Th0

Th1

Simultaneously produces IFNg while downregulating the receptor - so that IFNg only inhibits Th2

Subtopic

Cytokines

IFNg

Inhibits growth when bound to receptor

GM-CSF

IL2

TNFa

CD8+

Cytotoxic T cell + Macrophages

B Cell

Plasma B Cell

IgE

IgG

Immunoglobulin

A: Mucosal immunity (passive)

E: Mast Degranulation - hypersensitivity

G: Opsinization, complement, passive immunity

M: Complement activation

VDJ recomb

AID1

Rag

Basophil (Inflam)

Eosinophils (Parasites)

Monocytes/MDM (phagocytes)

Neutrophils

makes compliment (as does liver)

Inflammation

Phagocyte

Mast Cells

target of corticosteroids

Inflammatory