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Larger doses of LSD give the greatest reactions. Some examples of the reactions that can be expected are intense anxiety, paranoia, and psychosis. In addition, other factors need to be considered such as if the drug was taken in an anxiety-inducing environment (Hart and Ksir, 2022).
In 1974 the New York Times published an article that spotlighted the illegal activities of Project MK-Ultra. The following year, an investigation was conducted to uncover the truth about this operation (History.com, 2018).
The Church Committee was a larger investigation that looked further into the abuse of the CIA, FBI, and other U.S. intelligence agencies. It uncovered a great amount of evidence tied to the experiments conducted in MK-Ultra (History.com, 2018).
This led to President Ford's Executive Order that prohibits the use of drugs for experiments on human subjects. Unless given informed written consent that is witnessed by a disinterested party (History.com, 2018).
Some people consented to LSD experiments. Some of these individuals included the Grateful Dead lyricist Robert Hunter, the Unabomber Ted Kaczynski, and the notorious mobster James Joseph "Whitey" Bulger (History.com, 2018).
There is evidence that operations such as Midnight Climax existed that had little to no supervision. Midnight Climax was a project within MK-Ultra that used prostitutes to lure men into CIA safehouses. The men would be drugged and their reactions would be recorded. A CIA agent would sit behind a two-way mirror and take note of the men's behavior. It has been documented that these agents would indulge in a cocktail while performing their experiments (History.com, 2018).
In the early 1950's the CIA paid $240,000 to purchase the world's entire supply of LSD. It was given to hospitals, clinics, prisons, and other institutions (Gross, 2019).
The CIA unintentionally brought LSD into the United States. From the time it was introduced and distributed it became widely popular. It gave way to the hippie culture (Gross, 2019).