Systemic inflammatory response syndrome (SIRS)

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Innate immunity

Ved Buchro Duera-oh

Wound Healing

Ved Dave Brown

Plasma Proteins

Ved Kay Violet

SUICIDE

Ved Mabel Mabel

Systemic inflammatory response syndrome (SIRS)

ETIOLOGY

Combination of several “insults"

Infection

Trauma

Inflammation

Ischemia

PATHOGENESIS

Preoperative Illness

Trauma or Operation

Tissue Ingury

Excessive Inflammatory Response

Inadequate Resuscitation

SIRS/MOD

Optimal Oxygen Therapy

Recovery

CRITERIA (When any 2 or more of these are observed at a time SIRS is confirmed)

Heart rate >90 beats per minute

Fever >38◦C or < 36◦C

Abnormal white blood cell count (>12,000/mm3 or <4,000/ mm3 or >10% bands

Respiratory rate >20 breaths per minute or PaCO2 <32 mm Hg