Loop Diuretics

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Loop Diuretics

Prototype Drug

Lasix (trade)

furosemide (generic)

Med examples

torsemide (Demadex)

furosemide (Lasix)

bumetanide

Ethacrynic acid (Edecrin)

Nursing Considerations

* do not use in pts' with severe renal failure * monitor serum electrolytes, glucose, and uric acid with use and hematology, liver function tests * obtain W daily, monitor UO * use cautiously in pts' with gout

Off label uses

ascites

pulmonary edema

reducing Intra ocular pressure from glaucoma

Side Effects/Adverse Effects

Dehydration, electrolyte imbalances, hypotension, ototoxicity

Mechanism of Action

Conditions Treated: * hypertension * edema associated w/heart failure * severe hypercalcemia

Therapeutic Effects: * reduces BP through vasodilation * reduces edema/pulmonary congestion * decreased workload on heart

Blocks chloride pump in ascending loop of Henle, decreasing reabsorption of Na+ and 2Cl-, causing their excretion in the urine. Reduces blood volume and cardiac workload by increasing urine output.