Myocardial Performance

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Myocardial Performance

Afterload

Cardiac Remodeling Prevention

Labetalol

Carvedilol

Aldosterone antagonists

ARBs

Blocks locally produced AgII

ACE inhibitors

Pregnancy

Kidney-sparing

Dry cough

Captopril

Renin antagonist

Aliskiren

PDE5 Inhibitors

Priapism

Does your erection last for more than 4 hours?

Pulmonary HTN

↑cGMP

Tadalafil (Cialis)

(36h)

Vardenafil (Levitra)

V = Very quick onset

Sildenafil (Viagra)

Subtopic

Arterial relaxants

Always use w/ BB + Diuretic

You need to block the compensatory effects of the baroreceptor reflex.

Pinacil

PO

Minoxidil

Hypertrichosis

Hydralazine

Lupus-like syndrome

IV

Diazoxide

Hyperglycemia

Calcium-channel blockers

GI Problems

Edema

Facial flushing

Cardiosparing

Nifedipine

Diltiazem

Verapamil

Alpha-1-blockers

1st-pass Syncope

Terazosin

Doxazosin

Lipid Profile

↓LDL

↑ HDL

Long-acting

Prazosin

Heart Rate

Goal of Therapy

Decrease HR --> Increase filling time --> Increase cardiac output

↑Vagal tone

Calcium channel blockers

Beta-blockers

Preload

Other

Morphine

Think PBL case

Nitrates

Hypotension

Flushing, Burning

Headache

Angina prophylaxis

Isosorbid dinitrate

Malignant HTN

Nitroprusside

Thiocyanate

B12

Reduces toxicity

Dx Use

Amyl nitrate

Inhalation

Acute angina

Nitroglycerin

Almost every route

Diuretics

Contractility

Digoxin