Antiemetic in chemotherapy, radiation and postoperatively
An ion channel (no 2nd messengers)
Found in area of posterma, peripheral sensory and enteric nerves
5HT 2(a-c)
Cyproheptadine
Has H1 blocking effects, so it's used for seasonal allergy
Octreotide is a better drug however
Antagonist for HT2 in carcinoid and G.I tumors
Olanzapine
Antipsychotic
5HT 2a antagonist
In periphery: Vasodilation (flushing), contraction of G.I muscles (diarrhea), contraction of bronchioles, uterine smooth muscles and platelet aggregation
Found in CNS (excitatory)
5HT 1(a-h)
Sumatriptan
Side effects: possible asthenia, throat or chest pain
Lowers migrain pain by causing vasoconstriction
Agonist at 5HT 1d in cerebral vessels
buspirone
Anxiolytic (Generalised anxiety disorder, GAD)
Remember "a for anxiety"
