SIDEROBLASTIC ANEMIA

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Rheumatoid Arthritis

由Anthony Traboulsi

Organophosphate Poisoning

由Brian Rystad

Toronto Water Supply

由Edward Stan

Malaria

由PB - 10BD 908819 North Park SS

Kidney

Treatment

Bone Marrow Transplant

Iron Chelating agents

Therapeutic phlebotomy

Administer Vit B6

Removal of toxins

Diagnostic Lab

Iron studies

Decreased Total Iron Binding capacity

Increased ferritin

Increased serum iron

Peripheral blood smear

Pappeheimer bodies in RBC

Basophilic stipling

CBC

MCV

Normal or High

Ringed Sideroblast

Lead Poisoning

Denatures ribonuclease - build up of ribosomes in RBC

Denatures enzymes necessary for Heme synthesis

Vitamin B 6 deficiency

Mitochondria's ability to form Heme

ETOH abuse

Mitochondrial damage

Small Intestine

Stomach

Brenda Mitchell

Heart

Lungs

Decreased RBC increase serum iron

Arterial System

Body Cells

Liver

Iron stored as Ferritin

Bone Marrow

Pluripoint stem cells

Decreased heme production

Increased Iron

Iron accumulates in mitochondria

Build up of ribosomes

Basophilic stimpling

Mitochondria surround nucleus

Excess Iron Deposits

Immature RBCs

Excess Iron builds up in organs and cause damage

Sternum, Pelvis, Vertebrae

Spleen

DIETARY IRON

SIDEROBLASTIC ANEMIA