TRH neuron

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Hypothalamic Pituitary Axis-Prolactin

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TRH Receptor on Pitutary

T4

Liver

Auditory

Skeletal Muscle

All aspects of thyroid hormone synthesis and secretion as well as cell growth

Stimulates PKC

TSH Receptor on Thyroid

TSH Synthesis and secretion

Stimulates Ca2+ and PKC

TRH Neuron

Metabolic responses

T3

Heart

Bone

Brain

Thyroid

****Insert image of thyroid epithelial cell ***

Pituitary

Hypothalamus

TRH neuron

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Contains TRH receptor

Ca2+ and PKC stimulate THS synthesis and secretion

Pituitary thyrotrope cell

Link to Mindomo

Thyroid epithelial cell

Releases TRH to the Pituitary thyrotrope cell