TRH neuron
TRH Receptor on Pitutary
T4
Liver
Auditory
Skeletal Muscle
All aspects of thyroid hormone synthesis and secretion as well as cell growth
Stimulates PKC
TSH Receptor on Thyroid
TSH Synthesis and secretion
Stimulates Ca2+ and PKC
TRH Neuron
Metabolic responses
T3
Heart
Bone
Brain
Thyroid
****Insert image of thyroid epithelial cell ***
Pituitary
Hypothalamus
TRH neuron
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Contains TRH receptor
Ca2+ and PKC stimulate THS synthesis and secretion
Pituitary thyrotrope cell
Link to Mindomo
Thyroid epithelial cell
Releases TRH to the Pituitary thyrotrope cell