EFFECT OF FREE RADICALS

Mer som dette

Manipulating, Researching, and Cloning DNA and Genes

Ved Lillian Hyde

Types of Cellular Injury

Ved Chan Samuel

Antitumor Antibiotic

Ved R G

Macromolucle

Ved Jaimin Ashra

EFFECT OF FREE RADICALS

PTN cross linking

cystine - lysine - methionine - histidine

enzyme inactivation :Sulfa-hydral enzyme

DNA damage

3- Mutations or cell Killing

2- single strand DNA

1- free radical with thymine =Oxidation

Non-peroxidative mito mem damage

Fenton reaction

Xanthene oxidase

lipid peroxidation of Membranes

free radical attach to double bond of mem form : Lipid peroxide

this LIPID peroxide: unstable & Reactive= extensive damage to All membranes